Interactions & Contraindications: A 2025 Safety Checklist for Bupropion By Oliver Freudenreich, MD  | Medically reviewed by Graham Thornicroft, MBBS, PhD, FRCPsych  | Last updated:7 May 2025 CYP2B6 Inhibitors: When Bupropion Levels Spike Bupropion is primarily metabolized via cytochrome P450 2B6 (CYP2B6) into hydroxybupropion its most pharmacologically active metabolite. Inhibition of this pathway can lead to a significant rise…

Abilify Lawsuit Updates 2025: Current Litigation and Regulatory Landscape Background of the Abilify Lawsuit: Gambling and Hypersexuality Allegations The Abilify lawsuit has its origins in mounting reports of compulsive behaviors, most notably pathological gambling and hypersexuality, among patients prescribed aripiprazole. These behaviors, which emerged in post-marketing surveillance and case series, were not initially highlighted in…

Off-Label Bupropion Uses: ADHD, Bipolar Depression and Beyond Medically reviewed by Graham Thornicroft, MBBS, PhD, FRCPsych  | Last updated:7 May 2025 Why Bupropion Is Considered for Off-Label Use Off-label prescribing refers to the use of an approved medication for an indication not specifically authorized by regulatory agencies. While this may sound experimental, it's a routine and evidence-informed aspect…

Does Bupropion Boost Libido? Real-World Evidence & Patient Stories Survey Data: Reddit 2019 and FSFI Outcomes Study 2022 Sexual side effects remain one of the most common reasons people discontinue antidepressants. Bupropion (Wellbutrin®), unlike SSRIs, is frequently reported to either preserve or improve libido. In fact, it has become a frequent topic on forums like…

Bupropion & Sexuality: Managing Antidepressant-Induced Sexual Dysfunction (AISD) in 2025 Why Bupropion Matters in Treating Antidepressant Sexual Side Effects Sexual dysfunction is one of the most common and underreported side effects of antidepressant therapy. Among individuals taking selective serotonin reuptake inhibitors (SSRIs), rates of sexual dysfunction range from 30% to as high as 70%, depending…

Sildenafil 100 mg: Psychophysiological Profile & Role in SSRI-Induced Sexual Dysfunction Generic Viagra (sildenafil 100 mg) has become a cornerstone in the management of SSRI-induced sexual dysfunction (SSRI-SD), a common and distressing side effect of modern antidepressant therapy. This 2025 review synthesizes the latest clinical evidence, pharmacology, and telehealth access pathways for patients and clinicians…

Bupropion vs Varenicline vs Cytisine: Which Works Best for Quitting? Mechanistic Differences: How Zyban, Chantix & Cytisine Work Pharmacologic treatments for tobacco dependence target the brain’s cholinergic and dopaminergic systems. Although all three agents—Bupropion (Zyban®), Varenicline (Chantix®), and Cytisine—reduce nicotine cravings and withdrawal symptoms, their mechanisms differ significantly. Bupropion is a norepinephrine - dopamine reuptake…

Bupropion for Smoking Cessation: Updated Cochrane Evidence & Clinical Practice (2025) Why Consider Bupropion Instead of Cold Turkey? Most people who try to quit smoking do so without medications like Bupropion commonly known as “going cold turkey.” Unfortunately, this approach has low success rates. Only about 3–5% of unaided quit attempts lead to long-term abstinence…

Bupropion + Naltrexone (Contrave): Synergistic Effects & Safety POMC Feedback Loop & β-Endorphin Blockade Contrave® is a fixed-dose combination of naltrexone and bupropion approved for chronic weight management. Its mechanism targets both the hypothalamic hunger pathways and the mesolimbic reward system, resulting in dual action on appetite and cravings. The key to its synergistic effect…

Bupropion for Weight Loss: Efficacy, Mechanisms & Clinical Evidence Why Consider Bupropion for Weight Management? Weight gain is a common and often distressing side effect of many antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs). Studies suggest that up to 25–30 % of SSRI users experience clinically significant weight gain within 6 to 12 months of…