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Does Bupropion Boost Libido? Real-World Evidence & Patient Stories

Survey Data: Reddit 2019 and FSFI Outcomes Study 2022

Sexual side effects remain one of the most common reasons people discontinue antidepressants. Bupropion (Wellbutrin®), unlike SSRIs, is frequently reported to either preserve or improve libido. In fact, it has become a frequent topic on forums like Reddit and in real-world outcomes research. In a 2019 Reddit thread with over 1,400 comments, the majority of users described increased desire, faster arousal, and more satisfying orgasm after switching to Bupropion.

Scientific data support these anecdotes. A 2022 patient-reported outcome study by Kennedy et al. (n = 1,122) found that 42% of respondents noted moderate to significant improvement in sexual functioning after initiating Bupropion (Kennedy SH et al. Patient-reported outcomes study (1 122 pts). J Sex Med 2022). Women, in particular, reported higher FSFI (Female Sexual Function Index) scores for desire and satisfaction domains. A separate cohort tracked by Rebbeck et al. also noted improvements after switching from SSRIs to Bupropion monotherapy (Rebbeck T et al. FSFI change after switch to bupropion. Arch Sex Behav 2020; ).

These reports reflect not only pharmacology but also the emotional context of sexual function. To learn more about the neurochemical basis of Bupropion’s effects, see our pharmacology overview.

Positive Narratives – Increased Desire, Easier Orgasm

Among users who saw benefits, the most frequent improvements related to libido and orgasm latency. One Reddit user shared: “I didn’t even realize how numb I felt until I switched to Wellbutrin. Suddenly, I wanted sex again and could actually enjoy it.” These types of stories aren’t isolated. Many describe rediscovering sexual pleasure after months or years of SSRI-induced flatness. In the Kennedy 2022 cohort, participants used terms like “returning to normal,” “spark came back,” and “finally feeling responsive.” Several patients also highlighted emotional connection as a parallel benefit, stating that the reemergence of desire enhanced intimacy with partners. This aligns with Bupropion’s dopaminergic mechanism, which supports reward sensitivity and attentional engagement critical factors in both emotional and physical intimacy.

Other quotes from patient forums include:

  • “I didn’t get a libido boost immediately, but three weeks in I was initiating again.”
  • “Wellbutrin gave me mental energy and somehow, sexual energy followed.”
  • “Not only do I want sex again, I’m able to finish. That alone is a game-changer.”

Negative or Neutral Experiences – Not for Everyone

While many report improved libido, others do not notice sexual benefits or experience side effects that offset gains. Commonly cited negatives include insomnia, anxiety, irritability, and headache. For individuals already prone to restlessness, Bupropion may worsen stimulation, making intimacy more difficult rather than easier. One user posted: “It helped my desire, but the jitteriness made me avoid touch altogether.”

About 20% of respondents in the 2022 study reported no change, and 11% noted worsening symptoms (Kennedy et al.). For some, the increase in libido wasn’t matched by physical arousal, leading to frustration. Others struggled with timing: “Sex drive was back but only at 10 p.m., when my partner was asleep.” These mismatches underscore that libido is complex and multidimensional.

Side effect burden often depends on dose, timing, and co-medications. In cases where stimulation is excessive, reducing Bupropion dose or using the SR formulation instead of XL may help. If you’re considering options, check our AISD evidence guide for structured comparisons.

How to Discuss Libido Concerns with Your Clinician

Bringing up sexual side effects can feel awkward but it shouldn’t be. Loss of libido, difficulty with arousal, or inability to climax all have real emotional consequences. Fortunately, clinicians are increasingly aware of antidepressant-induced sexual dysfunction (AISD) and options like Bupropion that may help. When possible, prepare a brief summary of what’s changed, how long it’s been happening, and what you’ve tried.

Sample phrases to use:

  • “I’ve noticed a drop in sexual desire since starting [medication]. Is that common?”
  • “I’ve heard Wellbutrin might help with SSRI-related sexual side effects. What do you think?”
  • “Is there a way to address intimacy concerns without stopping my antidepressant?”

For many patients, switching or augmenting with Bupropion can offer relief without sacrificing mood stability. However, individual response varies. A collaborative approach including your doctor, partner, and perhaps a therapist can maximize outcomes.

Resources & Next Steps

If you’re considering Bupropion for libido or general well-being, there are multiple entry points. First, check whether your symptoms fit with antidepressant-induced sexual dysfunction. Then, explore both medical and experiential sources. You can review structured clinical data in our AISD evidence pillar, understand drug mechanisms in our pharmacology article, or compare pharmacy access via our where to buy Bupropion guide.

We also recommend:

  • Talking with your provider about a short-term Bupropion trial (typically 150–300 mg/day)
  • Tracking changes in desire, arousal, and orgasm over 4–6 weeks
  • Engaging in open communication with your partner to realign expectations

Finally, don’t forget to share your voice. Real-world experiences are vital to destigmatizing sexual health concerns and shaping future care. If you’re comfortable, consider participating in surveys, anonymous forums, or patient panels that amplify the lived reality of AISD.