Bimonthly, Established in 1959
Open access journal

Systematic review and meta-analysis

PsychosociaI rehabilitation in Schizophrenia

Ying CHEN,Hong DENG,ShanMing LIU,ShuSen ZHANG

Abstract:It has long been known that the best outcomes for patients with schizophrenia occur when medication treatment is combined with some form of psychosocial rehabilitalion.Empiriclly supported treatments for schizophrenia now include a variety of psychosocial interventions,such as family intervention,psycho-education,behavior therapy,cognitive remediation therapy,cognitive behavioral theraay and social skills training.We review the literature on psychosocial intenrentions published in domestic and intemational joumals.Most of these methods have proven effective at improving the social functioning of schizophrenic patients in research studies but the efficacy of these methods in standard clinical practice remaim uncertain.

Key words:Psychosis;Schizophrenia;Psychosocial treatment;Rehabilitation

Original research article

Comparison of brainstem auditory evoked potentiaIs in generaIized anxiety disorder and obsessive compulsive disorder
JiaWen LUO,ChangAn LI,HeXun SHl,GuiBi QIAN,YunXiang TANG,Yi CUl
Adjunctive treatment with transcranial magnetic stimulation in treatment resistant depression:a randomized, double-blind, sham-controlled study
XuanHong ZHANl,LiWei WANG,Ji Jun WANl,Qiang LlU,Ye FAN

Background:High-frequency repetitiVe transcranial magnetic stimulat;on(rTMS) promising antidepressant treatment but the appfopriate duration of treatment and in treatment res.stant Datients is uncertain. to the left DrefrontaI cortex is a b effbd on cogn;tive symptoms 

Hypothsis:PatientS with treatment resistant depression on standard antidepressant medication who receive four weeks of adjunCtive treatment with high—frequency rTMS to the leR prefrontaI conex will have better cIinicaI out. comes and better cognitive functioning than those who receive Sham rTMS treatments.
Methods:Thirty patientS with treatment resistant depression(defined as failure to respond to two or more antide. pressants of differenl classes administered for at leasl 6 weeks at or above two.thirds of the recommended maximum dose)receiving Selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhjbitors were randomly assigned to receive adjundive treatment with either real rTMS(n=1 5)or sham rTMS(n=1 5)5 times a week for 4 conseculive weeks.Blinded pre—post evaIuations were conducted using the 17-item HamiIton Depression Rating ScaIe(HAMD),the Montgomery—Asberg Depression Rating Scale(MADRS),the severity of ilness measure from the CinicaI GlobaIlmpression rating scaIe(CGI-S),the Wechsler AduIt Intelligence ScaIe(WAIS), the Wechsler Memory scaIe (WMS),and the Wisconsin Card Sorting Test(WCST)。
Results:14 subiects from each group completed the study.There was no significant difference in the HAMD total scores between the two groups after 2 weeks of treatment but after 4 weeks of treatment the mean percentage drop in the HAMD total score was significantly greater in the real rTMS group(49%,SD=1 9%)than in the sham rTMS group(29%,SD=25%),with a mean difference of 20%【95%a=3%_37%;k=2.42;P=0.023】.At 4 weeks the mean(SD)reduction in the MADRS total Score was also greater in the real rTMS group f47%(23%)vs 1 6% (40%),Mann—Whitney Z=2.62,P=O.009l,but there was no significant difference in the reduction of CGl-S Scores-between the two groups.Neither of the groups had signjficant pre-post changes in intelligence,memory or executive functioning.
Conclusion:Repetive transcranial magnetic stimulation is an effective adjunctive treatment for the affective symptoms of treatment resistant depression if administered for functioning.
Keywords:Treatment resistant depression;Repetitive transcranial magnetic stimulation(rTMS);Efficacy;Cognitive functions
Prevalence and rIsk factors of diabetes in schizoprenia inpatients
DaChun CHEN,BaoHua ZHANG,ZhiRen WANG,WuFaIlg ZHANG,YunIong TAN,XiangYang ZHANG
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