Aims: To measure the changes in cognitive functioning in patients with primary insomnia.

Background: Schizophrenia is characterized by abnormal perception, thinking, emotions, and behaviors.Cognitive dysfunction is acknowledged as one of the most pivotal symptoms in schizophrenia. In addition to positive or negative symptoms, which had been proposed by Gallhofer in the early 1970s, schizophrenia patients suffered from cognitive impairments as well. Many studies show that there is genetic susceptibility in the first grading kinship of patients with schizophrenia. Patients with schizophrenia have cognitive impairment not only in the acute phase but also in the stable phase. Studies also show that the healthy first-grading relatives of patients with schizophrenia suffer from cognitive defects. However, there is still a lack of studies about the cognitive features of biological parents of those with schizophrenia. In this study,we speculate the biological parents of schizophrenia patients have specific cognitive dysfunction. And we explore the patterns of cognition among both schizophrenia patients and their biological parents using the Chinese version of MATRICS Consensus Cognitive Battery (MCCB). 

Background: Pregnancy is a period of transition, which makes women more vulnerable and in unfavorable conditions may lead to psychopathology in both mother and infant. It is essential to outline factors adversely affecting the resolution of this period. Early interventions and why they matter: Interventions during pregnancy can provide important improvement in the outcome for both maternal and infant mental health. 

Background: Serotonergic system dysfunction has been implicated in obsessive-compulsive disorder (OCD).This study examined peripheral SLC6A4 gene expression in OCD patients and healthy controls to explore the relationship between SLC6A4 and OCD. 

Case report

Summary: Hyponatremia is a rare, yet potentially life threatening complication of antipsychotics. Here,we report a case of a 45-year-old female diagnosed with schizophrenia who developed hyponatremia soon after addition of olanzapine to the existing treatment. This prompted us to evaluate the relationship between hyponatremia and olanzapine, as timely management is crucial. Naranjo algorithm established a “probable” causal relation between olanzapine and hyponatremia. Possible etiological reasons of this clinically significant and life threatening adverse event have been discussed. We report the case and the literature focusing on hyponatremia as a possible adverse event of olanzapine. Medical illnesses are often ignored or missed in patients with psychiatric disorders either due to patients’ inability to report complaints or non-serious attitude of physicians towards such patients. A high index of suspicion should be kept while dealing with this probable complication. 

Summary: Compulsive water drinking or psychogenic polydipsia is now increasingly seen in psychiatric populations. Effects of increased water intake can lead to hyponatremia causing symptoms of nausea,vomiting , seizures, delirium and can even be life threatening if not recognized and managed early. Here we present a 35-year old adult who was diagnosed with psychogenic polydipsia and was successfully managed with a combination of pharmacotherapy, fluid restriction and psychosocial management. 

Summary: Hashimoto’s thyroiditis is a rare condition associated mainly with neurological symptoms. It contains an abundant amount of auto-antibodies in the blood. Only a few cases of behavioral symptoms without significant neurological disturbances have been recorded in the literature. In this view, our case is unique as it was not associated with overt hypothyroid manifestations.