Bimonthly, Established in 1959
Open access journal

Combining antidepressants

David L Dunner


Treatment-resistant depression is a common problem encountered by psychiatrists. These patients are often difficult to treat effectively. Strategies for addressing patients with treatment-resistant depression include changing medications, adding another antidepressant (antidepressant polypharmacy), and augmenting treatment with a non-antidepressant.

Keywords: Treatment-resistant depression; antidepressant polypharmacy; augmentation; switching antidepressants.