Bimonthly, Established in 1959
Open access journal

A Comprehensive Review of Epilepsy’s Origins 2024

Epilepsy, a complex neurological condition, has intrigued and challenged the medical community for centuries. With symptoms ranging from mild sensory disruptions to severe and frequent seizures, understanding its origins is crucial for developing effective treatments. This collection of articles from 2024 delves into the various factors contributing to epilepsy, including genetic predispositions, biochemical imbalances, and structural changes in the brain post-injury. Each article provides valuable insights into how epilepsy manifests and progresses, offering a comprehensive look at the latest research in this field. These articles not only highlight the diversity of epilepsy’s causes but also underscore the importance of a multifaceted approach to its study and management.

Health Care Disparities in Morbidity and Mortality in Adults with Acute and Remote Status Epilepticus: A National Study

Authors: Gabriela B. Tantillo, Deepa Dongarwar, Chethan P. Venkatasubba Rao, Amari Johnson, Stephanie Camey, Oriana Reyes, Mariana Baroni, Jaideep Kapur, Hamisu M. Salihu, Nathalie Jetté

Abstract/Summary: This study investigates disparities in the care of patients with status epilepticus (SE) and associated outcomes using data from the National Inpatient Sample between 2010 and 2019. Key findings include significant disparities in SE prevalence and management across demographic lines, such as race, age, and income. Results indicated higher prevalence and worse outcomes for older adults, non-Hispanic Blacks, and lower-income groups. Access to crucial interventions like EEG monitoring was significantly influenced by socio-economic status and hospital location (urban vs rural). This study underscores the need for focused attention on vulnerable populations to enhance health outcomes and reduce disparities in epilepsy care. (Wiley)

Authors: Roberta Di Giacomo, Alessandra Burini, Daniela Chiarello, Veronica Pelliccia, Francesco Deleo, Rita Garbelli, Marco de Curtis, Laura Tassi, Vadym Gnatkovsky

Abstract/Summary: This study explores the utility of “ictal fast activity chirps” as a biomarker for identifying the epileptogenic zone (EZ) in patients undergoing focal epilepsy surgery. The research analyzed frequency content of stereoelectroencephalography (SEEG) signals in 176 patients with either cryptogenic focal epilepsies or those with inconsistent clinical and anatomical data. Findings show that chirps were identified in 95.4% of these patients, suggesting a high reproducibility of this pattern across diverse etiologies and locations of EZ. A strong correlation was observed between the precise localization of chirps and successful surgical outcomes, specifically in patients achieving an Engel class Ia outcome. In contrast, discrepancies between chirp locations and visually determined EZ were associated with poorer surgical results. This confirms the potential of chirps as reliable indicators of the EZ in a clinical setting.(Wiley)