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Commentary on “Testosterone Deficiency and Erectile Dysfunction: A Practical Approach to Diagnosis and Management”


Dr. John Davis, Dr. Linda Carter


Department of Urology, Metropolitan Medical Center


Dr. John Davis, Department of Urology, Metropolitan Medical Center


The article by Eric Chung et al., “Testosterone Deficiency and Erectile Dysfunction: A Practical Approach to Diagnosis and Management,” provides a comprehensive overview of the interplay between testosterone deficiency (TD) and erectile dysfunction (ED), outlining a practical approach for the diagnosis and management of these conditions. While this article serves as a valuable resource for primary care physicians, there are several areas where the discussion could be expanded to enhance understanding and application in clinical practice.

Firstly, the article effectively highlights the importance of testosterone in maintaining erectile function and the physiological mechanisms through which testosterone modulates sexual desire and response. However, the discussion could benefit from a deeper exploration into the non-androgenic factors that may contribute to ED in the context of TD, such as psychological factors, lifestyle, and vascular health. Addressing these components could provide a more holistic view of patient care.

Secondly, while Chung et al. recommend a range of diagnostic tests including fasting glucose, cholesterol, lipids, and testosterone levels, the commentary could extend into the newer biomarkers and imaging techniques that may improve diagnostic accuracy for underlying pathologies contributing to ED. For instance, penile Doppler ultrasound could be discussed as a method to assess vascular status in patients with ED.

Moreover, the article briefly mentions the combination therapy of testosterone replacement therapy (TRT) and phosphodiesterase type 5 (PDE5) inhibitors but does not delve deeply into the criteria for selecting this combination, patient eligibility, or timing of treatment initiation. A detailed discussion on these aspects would be highly beneficial, particularly in providing clarity on managing patients unresponsive to single-modality therapy.

Additionally, the authors outline the necessity of regular follow-up to assess the efficacy and safety of TRT, a crucial aspect of managing patients with TD and ED. Expanding this discussion to include specific monitoring protocols, potential adjustments in therapy based on patient response, and long-term management plans would enhance the practical utility of the review.


The review by Chung et al. is an informative piece that adds significant value to the field of sexual medicine. However, by broadening the discussion to include a more integrated approach to the factors contributing to ED, elaborating on advanced diagnostic and treatment modalities, and providing detailed guidance on the management of TRT in combination with PDE5 inhibitors, the article could further its applicability in clinical settings. Enhancing these areas would ensure that the article not only serves as a practical guide for the initial management of TD and ED but also as a comprehensive resource for ongoing patient care.


  1. Chung E, Al-Bermani OS, Fowler RP, Gillman MP (2013) Testosterone Deficiency and Erectile Dysfunction: A Practical Approach to Diagnosis and Management. J Endocrinol Diabetes Obes 1(2): 1012.