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Commentary on “Management Strategies for Antidepressant-Related Sexual Dysfunction: A Clinical Approach” by Angel L. Montejo et al.

Journal of Clinical Medicine, 2019, 1640;


The article by Montejo et al. addresses the clinically significant yet often under-discussed issue of treatment-emergent sexual dysfunction (TESD) associated with antidepressant medication. Recognizing the bidirectional relationship between depression and sexual dysfunction, the authors provide a comprehensive review of management strategies that could potentially alleviate TESD without compromising the antidepressant efficacy.

Core Concepts and Methods:

TESD, a common side effect of antidepressant therapies, particularly those involving serotonin reuptake inhibitors (SSRIs), can significantly impact treatment adherence and patient quality of life. Montejo and colleagues methodically review the incidence, implications, and intervention strategies for TESD, drawing from a wide array of literature encompassing clinical trials, observational studies, and systematic reviews. The authors emphasize the necessity of proactive measures by clinicians, including the selection of antidepressants with lower incidences of sexual side effects and routine monitoring for TESD.

Principal Findings:

  1. Incidence and Impact: The article reiterates that TESD is remarkably prevalent, yet routinely underestimated in clinical practice. This underestimation contributes to non-adherence and decreased quality of life, reinforcing the need for clinicians to address this issue openly and proactively.
  2. Management Strategies: Several strategies are discussed:
    • Preventive Measures: Choosing antidepressants with a lower risk of TESD, such as bupropion, mirtazapine, or agomelatine.
    • Pharmacological Adjustments: Adjusting the dosage, “drug holidays,” switching to another antidepressant, or adding a medication to counteract TESD (e.g., phosphodiesterase type 5 inhibitors, or PD5-Is, for erectile dysfunction).
    • Psychoeducational Approaches: Educating patients about potential sexual side effects and discussing them openly to mitigate their impact.
  3. Recommendations for Clinical Practice: The authors advocate for a tailored approach, where the choice of strategy is informed by individual patient needs and the specific nature of their sexual dysfunction. This personalized strategy should aim to maintain antidepressant efficacy while minimizing the impact on sexual function.

Critical Analysis:

Montejo et al. effectively highlight an important clinical problem, providing a structured overview of potential solutions. However, the complexity of TESD, influenced by psychological, relational, and biological factors, suggests that no single strategy will be universally effective. The article could benefit from a deeper exploration of the role of psychological interventions, such as cognitive-behavioral therapy, which can be crucial for some patients.

Moreover, while the article provides a detailed review of pharmacological strategies, it may underrepresent the importance of integrating mental health professionals, such as sex therapists, into the treatment plan. Collaborative care models involving a team of healthcare providers could potentially offer more comprehensive management strategies for patients suffering from TESD.


The article by Montejo et al. is an invaluable resource for clinicians, shedding light on a frequently overlooked side effect of antidepressant medication. By offering a range of management strategies and emphasizing the importance of clinician awareness, it contributes significantly to the literature on sexual dysfunction and mental health. Future research should focus on longitudinal outcomes of these management strategies and explore the integration of multidisciplinary approaches to enhance patient care in this complex area.