Bimonthly, Established in 1959
Open access journal

Critical Insights on the Neuropsychiatric Implications of Levetiracetam: A Response to Recent Case Findings

Title: Reevaluating the Neuropsychiatric Safety of Levetiracetam: Commentary on a Case of Levetiracetam-Associated Delirium

Authors: Dr. Jane Doe, Dr. John Smith

Affiliations: Department of Psychiatry, University Hospital

Correspondence: Dr. Jane Doe, University Hospital, Psychiatry Department


In the recent case report published by Jerry McKee1,2*   Barclay Driscoll PY-41   David Manly1   Christine Urbaniak2  in the Annals of Psychiatry and Mental Health titled “Levetiracetam-Associated Delirium in an Adult Male – A Case Report,” the authors meticulously detail an episode of acute delirium following the administration of Levetiracetam in a middle-aged male with no prior history of cognitive impairment. This case is instrumental in highlighting an often-overlooked adverse effect of a widely used anticonvulsant. However, several aspects of the case warrant a closer examination to better understand the implications of Levetiracetam use in clinical practice.

Firstly, the diagnosis of delirium was rapidly established based on symptomatic presentation, which included confusion, agitation, and perceptual disturbances. While the temporal association with Levetiracetam initiation is compelling, the report does not discuss the exclusion of alternative etiologies extensively. Delirium is multifactorial; factors such as metabolic disturbances, concurrent medication use, or even pre-existing undiagnosed neurocognitive disorders can precipitate similar clinical pictures. A thorough evaluation of these possibilities is crucial before attributing causality to Levetiracetam.

Secondly, the discussion section of the case report briefly mentions the pharmacodynamic properties of Levetiracetam but lacks a detailed mechanism by which the drug might induce delirium. Levetiracetam is known to modulate neurotransmitter release through its action on synaptic vesicle proteins, which could theoretically disrupt normal neurocognitive function. Further exploration into the neurochemical pathways affected by Levetiracetam could provide valuable insights into its neuropsychiatric profile.

Additionally, the patient’s rapid recovery upon discontinuation of Levetiracetam and initiation of antipsychotic treatment is indeed consistent with a drug-induced delirium. However, the role of the antipsychotic medication used to manage the symptoms could also be considered as a confounding factor in the rapid resolution of the delirium. Could it be possible that the antipsychotic itself had a primary effect in alleviating the delirium, independent of the cessation of Levetiracetam?

Lastly, while this single case adds to the growing literature on the potential neuropsychiatric effects of Levetiracetam, it raises the question of whether current clinical monitoring practices are sufficient for early detection of such adverse effects. It might be beneficial for clinicians to adopt more vigilant neuropsychiatric monitoring when prescribing Levetiracetam, especially in populations at risk for cognitive disturbances.


The case report by [Original Authors] serves as an important reminder of the neuropsychiatric risks associated with Levetiracetam. While it effectively captures the complexities of diagnosing and managing drug-induced delirium, it also opens several avenues for further research and discussion. As clinicians, it behooves us to remain circumspect about the broader cognitive impacts of the medications we prescribe and to ensure rigorous monitoring to safeguard patient well-being.


  1. Jerry McKee1,2*   Barclay Driscoll PY-41   David Manly1   Christine Urbaniak2 . (2024). Levetiracetam-Associated Delirium in an Adult Male – A Case Report. Annals of Psychiatry and Mental Health.