Bimonthly, Established in 1959
Open access journal

In This Issue:

Systematic Review and Meta-Analysis

The Role of Microbiota in Depression and Anxiety Disorders

Zhen WANG, Mei LI

Summary: The interplay between gut microbiota and the central nervous system—often referred to as the gut-brain axis—presents a promising field of research in understanding the biological underpinnings of mood disorders. This review systematically examines the burgeoning body of literature exploring the impact of gut microbiota on depression and anxiety, elucidating potential neurochemical pathways involved. Despite promising findings, discrepancies persist across studies, likely due to methodological differences, sample diversity, and challenges in accurately assessing microbiota.

Keywords: microbiota, depression, anxiety, gut-brain axis, systematic review

Original Research Article

Efficacy of Cognitive Behavioral Therapy for Chronic Pain: A Long-term Study


Background: Chronic pain affects a significant portion of the global population and severely impacts quality of life. Cognitive Behavioral Therapy (CBT) is recognized for its potential in managing chronic pain.

Aim: This study assesses the long-term efficacy of CBT in alleviating symptoms of chronic pain and enhancing psychological well-being.

Methods: We conducted a longitudinal study involving 235 patients at the Shanghai Pain Management Center from 2005 to 2010, comparing outcomes of those who received a 12-week CBT program to those under standard pain management.

Results: Patients undergoing CBT showed sustained improvements in pain perception and reduced psychological distress over five years compared to the control group.

Conclusion: The findings affirm the enduring benefits of CBT in chronic pain management, suggesting that psychological therapies could be integral to effective long-term treatment strategies.

Keywords: cognitive behavioral therapy, chronic pain, longitudinal study, psychological well-being

Randomized Controlled Trial

Comparative Efficacy of New Antipsychotic Compound X versus Olanzapine in Schizophrenia

Yi CHEN, Feng XU

Background: Schizophrenia requires effective long-term management. New pharmacological treatments are essential for enhancing patient outcomes.

Aim: To evaluate the efficacy and side effects of Compound X, a new antipsychotic, compared to olanzapine in treating schizophrenia.

Methods: In this double-blind trial, 86 schizophrenia patients at Beijing Psychiatric Hospital were randomly assigned to receive either Compound X or olanzapine over a six-month period. We used the Positive and Negative Syndrome Scale (PANSS) for efficacy assessment and monitored side effects.

Results: Compound X showed efficacy comparable to olanzapine but with significantly fewer adverse effects such as weight gain and sedation, suggesting better patient adherence potential.

Conclusion: Compound X appears as a promising antipsychotic alternative with fewer side effects, which could improve long-term treatment adherence.

Keywords: schizophrenia, antipsychotics, randomized controlled trial, new treatment, efficacy

Case Report

Seasonal Patterns in Bipolar Disorder Misdiagnosed as Seasonal Affective Disorder

Li JUN, Xiao SUN

Summary: We present a case of a 34-year-old male initially diagnosed with Seasonal Affective Disorder (SAD), whose symptoms and seasonal patterns ultimately revealed a diagnosis of bipolar disorder. This case emphasizes the need for thorough diagnostic evaluations in mood disorders, considering broader differential diagnoses beyond initial presentations.

Keywords: bipolar disorder, seasonal affective disorder, mood disorders, differential diagnosis, case report

Biostatistics in Psychiatry

Utilizing Machine Learning in Psychiatric Research: Methodological Considerations

Hao LI, Jing TIAN

Summary: Machine learning provides powerful tools for analyzing complex datasets in psychiatric research. This paper discusses key methodological challenges such as data heterogeneity and the risk of model overfitting, and offers recommendations for effectively applying machine learning techniques in this field.

Keywords: machine learning, psychiatry, methodological considerations, data analysis


Strategies for Integrating Mental Health Services into Primary Care in Rural China


Discussion: This forum article explores the integration of mental health services into primary care settings in rural China, discussing barriers, opportunities, and strategies for enhancing access to mental health care in these underserved areas.

Case Report

Neurological Impairments Following Long-term Benzodiazepine Use

Ming LIU, Zhao YANG

Summary: We report on a patient with a decade-long history of benzodiazepine use who developed significant cognitive impairments and neurological symptoms, emphasizing the importance of monitoring for these risks and managing long-term use cautiously.

Keywords: benzodiazepines, long-term use, neurological impairments, cognitive deficits, case report