Bimonthly, Established in 1959
Open access journal

In This Issue

Edited by Liwei Wang & Jinghong Chen

Systematic Review and Meta-Analysis

Meta-analysis of the Efficacy and Safety of Adjunctive Rosuvastatin for Dyslipidemia in Patients with Schizophrenia

Authors: Wei Zheng, Wei Yang, Qing-E Zhang, Xin-Hu Yang, Dong-Bin Cai, Jin-Qing Hu, Gabor S. Ungvari, Chee H.

Background: Metabolic syndrome is a major health concern among patients with schizophrenia, and the efficacy and safety of adjunctive rosuvastatin in treating dyslipidemia remain controversial.

Aims: This study aims to assess the efficacy and safety of adjunctive rosuvastatin for dyslipidemia in patients with schizophrenia.

Methods: A systematic search for relevant controlled clinical trials was conducted in databases including PubMed, PsycINFO, and Cochrane Library up to September 28, 2017. Standardized mean difference (SMD) and risk ratio (RR) along with their 95% confidence intervals (CIs) were calculated.

Results: Four studies involving 274 participants were identified. Adjunctive rosuvastatin showed greater efficacy than control in reducing LDL-C, total cholesterol, and triglycerides but not in increasing HDL-C. There were no significant differences in body weight, BMI, waist circumference, or fasting glucose levels. Adverse reactions and discontinuation rates were similar between groups.

Conclusions: Current data on the effectiveness and safety of adjunctive rosuvastatin in treating dyslipidemia for patients with schizophrenia are insufficient to draw definitive conclusions. Further high-quality RCTs are warranted.

Key Words: schizophrenia, rosuvastatin, dyslipidemia, LDL-C, meta-analysis


Original Research Article

The Clinical Effect and Dropout Rate of Drugs Combined with Group Integrated Psychotherapy on Elderly Patients with Depression

Authors: Bo Liu, Youguo Tan, Duanfang Cai, Yudiao Liang, Ruini He, Chengwen Liu, Yong Zhou, Cuihua Teng

Background: Group cognitive-behavioral therapy is effective in treating depressive disorders but has a high dropout rate. This study explores the effects of integrated group psychotherapy on elderly patients with depression.

Aims: To investigate the clinical effects and dropout rates of integrated group psychotherapy combined with pharmacological treatments in elderly patients with senile depression.

Methods: 100 elderly patients with senile depression were randomly divided into an experimental group (integrated group psychotherapy and pharmacological treatment) and a control group (cognitive-behavioral therapy and pharmacological treatment). Assessments were conducted using the Hamilton Depression Scale (HAMD-24) and Geriatric Depression Scale (GDS-15).

Results: Both groups showed significant improvement in HAMD and GDS scores post-treatment, with the experimental group showing greater compliance and a lower dropout rate.

Conclusions: Integrated group psychotherapy combined with medication significantly improves clinical outcomes and reduces dropout rates in elderly patients with depression.

Key Words: group integrated psychotherapy, cognitive-behavioral therapy, senile depression


Research on Geriatric Depression

White Matter Hyperintensity (WMH) and Factors Related to Geriatric Late-Onset Depression

Authors: Jinghua Wang, Wei Li, Ling Yue, Bo Hong, Na An, Guanjun Li, Shifu Xiao

Background: Geriatric depression is prevalent and harmful among the elderly, yet the relationship between late-onset depression (LOD) and brain structure, social, and psychological factors is under-studied.

Aims: To explore the factors related to LOD in elderly patients.

Methods: 24 LOD patients and 23 non-depressed elders were assessed using the Fazelas scale for WMH, the MTA-scale for medial temporal lobe atrophy, and demographic data.

Results: Significant differences were found in WMH scores, periventricular white matter hyperintensity (PWMH), religious beliefs, and family harmony between the LOD and control groups.

Conclusions: WMH, religious beliefs, and family harmony are potentially related to LOD in elderly patients.

Key Words: geriatric depression, late onset, MRI, white matter hyperintensity, religious belief, family harmony


Pediatric Psychiatry

Risk Factors of Nocturnal Enuresis in Children with ADHD

Authors: Habibolah Khazaie, Farshid Eghbali, Houshang Amirian, Mahmoud Reza Moradi, Mohammad Rasoul Ghadami

Background: ADHD negatively affects the resolution of nocturnal enuresis (NE), but few studies have investigated NE risk factors in ADHD patients.

Aims: To investigate the prevalence and risk factors of NE in children with ADHD.

Methods: 331 children with ADHD were assessed for NE prevalence and associated risk factors.

Results: NE was most prevalent in the inattentional subtype of ADHD. Risk factors included male sex, low parental education, history of neonatal sepsis, family history of NE, low birth weight, and caesarian delivery.

Conclusions: Children with ADHD, especially the inattentional subtype, have a high prevalence of NE. Identified risk factors should be considered in clinical management.

Key Words: nocturnal enuresis, ADHD, risk factors