Bimonthly, Established in 1959
Open access journal

In This Issue:

Edited by Liwei Wang & Jinghong Chen

Systematic Review and Meta-Analysis

Meta-analysis of Cognitive Behavioral Therapy for Major Depressive Disorder

Authors: John Smith, Mary Johnson, Robert Brown

Background: Cognitive Behavioral Therapy (CBT) is a widely used psychological treatment for Major Depressive Disorder (MDD). Its efficacy and safety compared to other treatments have been the subject of much research.

Aims: This meta-analysis aims to assess the efficacy and safety of CBT in the treatment of MDD.

Methods: Relevant controlled clinical trials were systematically searched in databases including PubMed, PsycINFO, and the Cochrane Library up to December 2009. Standardized mean differences (SMD) and risk ratios (RR) were calculated along with their 95% confidence intervals (CIs).

Results: The analysis included 20 studies with a total of 1,200 participants. CBT was found to be significantly more effective than control treatments (SMD: -0.89; 95% CI: -1.15, -0.62). CBT also showed lower dropout rates compared to pharmacotherapy alone.

Conclusions: CBT is an effective and safe treatment for MDD. Future studies should explore its long-term efficacy and compare it with other emerging therapies.

Key Words: Major Depressive Disorder, Cognitive Behavioral Therapy, Meta-analysis


Original Research Article

Long-term Effects of Antipsychotic Medication in Schizophrenia

Authors: Emily Davis, Thomas Green, Sarah Black

Background: The long-term use of antipsychotic medications in patients with schizophrenia is associated with both benefits and risks, including potential side effects and the impact on quality of life.

Aims: To evaluate the long-term effects of antipsychotic medications on symptom control and side effects in patients with schizophrenia.

Methods: This longitudinal study followed 300 patients with schizophrenia over a period of five years. Data were collected on symptom severity, medication adherence, and side effects.

Results: Long-term antipsychotic treatment significantly reduced symptom severity (p<0.001). However, 35% of patients reported moderate to severe side effects, including weight gain and metabolic syndrome.

Conclusions: While antipsychotic medications are effective in managing symptoms of schizophrenia, there is a significant risk of side effects. Strategies to mitigate these side effects should be considered.

Key Words: Schizophrenia, Antipsychotic Medications, Long-term Effects


Research on Geriatric Psychiatry

Cognitive Decline and Depression in Elderly Patients

Authors: Laura Thompson, Michael Lee, Katherine White

Background: Cognitive decline and depression often coexist in elderly patients, leading to increased morbidity and mortality.

Aims: To investigate the relationship between cognitive decline and depression in elderly patients and identify potential interventions.

Methods: The study included 150 elderly patients with varying degrees of cognitive decline and depression. Assessments were conducted using the Mini-Mental State Examination (MMSE) and the Geriatric Depression Scale (GDS).

Results: There was a significant correlation between cognitive decline and depression (r=0.56, p<0.01). Patients with severe cognitive decline had higher GDS scores.

Conclusions: Cognitive decline is closely associated with depression in the elderly. Early intervention and integrated treatment approaches are crucial for improving patient outcomes.

Key Words: Geriatric Psychiatry, Cognitive Decline, Depression


Pediatric Psychiatry

ADHD and Comorbid Conditions in Children

Authors: David Wilson, Jessica Brown, Rebecca Green

Background: Attention Deficit Hyperactivity Disorder (ADHD) often co-occurs with other psychiatric and developmental disorders, complicating diagnosis and treatment.

Aims: To explore the prevalence and impact of comorbid conditions in children with ADHD.

Methods: This study involved 250 children diagnosed with ADHD. Comorbid conditions were identified through clinical interviews and standardized diagnostic tools.

Results: 60% of children with ADHD had at least one comorbid condition, including anxiety disorders (30%), oppositional defiant disorder (20%), and learning disabilities (15%).

Conclusions: Comorbid conditions are common in children with ADHD and can complicate treatment. Comprehensive assessment and individualized treatment plans are essential.

Key Words: ADHD, Comorbid Conditions, Pediatric Psychiatry