Antipsychotics Beyond Dopamine: The Muscarinic Turn Medically reviewed by Paul E. Bebbington, MA, MPhil, FRCPsych; Phern-Chern Tor, MBBS; and Pichet Udomratn, MD | Last updated: 12 June 2025 Introduction For more than half a century, antipsychotic treatment has rested on the pharmacological foundation of dopamine D2 antagonism: the idea that attenuating hyperdopaminergic signaling in striatal circuits would quell hallucinations,…