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2011 Volume 23 Issue 1
Systematic review and meta-analysis
PsychosociaI rehabilitation in Schizophrenia Ying CHEN,Hong DENG,ShanMing LIU,ShuSen ZHANG Abstract:It has long been known that the best outcomes for patients with schizophrenia occur when medication treatment is combined with some form of psychosocial rehabilitalion.Empiriclly supported treatments for schizophrenia now include a variety of psychosocial interventions,such as family intervention,psycho-education,behavior therapy,cognitive remediation therapy,cognitive behavioral theraay and social skills training.We review the literature on psychosocial intenrentions published in domestic and intemational joumals.Most of these methods have proven effective at improving the social functioning of schizophrenic patients in research studies but the efficacy of these methods in standard clinical practice remaim uncertain. Key words:Psychosis;Schizophrenia;Psychosocial treatment;Rehabilitation
Original research article
Adjunctive treatment with transcranial magnetic stimulation in treatment resistant depression:a randomized, double-blind, sham-controlled study XuanHong ZHANl,LiWei WANG,Ji Jun WANl,Qiang LlU,Ye FAN Background:High-frequency repetitiVe transcranial magnetic stimulat;on(rTMS) promising antidepressant treatment but the appfopriate duration of treatment and in treatment res.stant Datients is uncertain. to the left DrefrontaI cortex is a b effbd on cogn;tive symptoms Hypothsis:PatientS with treatment resistant depression on standard antidepressant medication who receive four weeks of adjunCtive treatment with high—frequency rTMS to the leR prefrontaI conex will have better cIinicaI out. comes and better cognitive functioning than those who receive Sham rTMS treatments. Methods:Thirty patientS with treatment resistant depression(defined as failure to respond to two or more antide. pressants of differenl classes administered for at leasl 6 weeks at or above two.thirds of the recommended maximum dose)receiving Selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhjbitors were randomly assigned to receive adjundive treatment with either real rTMS(n=1 5)or sham rTMS(n=1 5)5 times a week for 4 conseculive weeks.Blinded pre—post evaIuations were conducted using the 17-item HamiIton Depression Rating ScaIe(HAMD),the Montgomery—Asberg Depression Rating Scale(MADRS),the severity of ilness measure from the CinicaI GlobaIlmpression rating scaIe(CGI-S),the Wechsler AduIt Intelligence ScaIe(WAIS), the Wechsler Memory scaIe (WMS),and the Wisconsin Card Sorting Test(WCST)。 Rsults:14 subiects from each group completed the study.There was no significant difference in the HAMD total scores between the two groups after 2 weeks of treatment but after 4 weeks of treatment the mean percentage drop in the HAMD total score was significantly greater in the real rTMS group(49%,SD=1 9%)than in the sham rTMS group(29%,SD=25%),with a mean difference of 20%【95%a=3%_37%;k=2.42;P=0.023】.At 4 weeks the mean(SD)reduction in the MADRS total Score was also greater in the real rTMS group f47%(23%)vs 1 6% (40%),Mann—Whitney Z=2.62,P=O.009l,but there was no significant difference in the reduction of CGl-S Scores-between the two groups.Neither of the groups had signjficant pre-post changes in intelligence,memory or executive functioning. Conclusion:Repetive transcranial magnetic stimulation is an effective adjunctive treatment for the affective symptoms of treatment resistant depression if administered for functioning. Keywords:Treatment resistant depression;Repetitive transcranial magnetic stimulation(rTMS);Efficacy;Cognitive functions
Comparison of brainstem auditory evoked potentiaIs in generaIized anxiety disorder and obsessive compulsive disorder JiaWen LUO,ChangAn LI,HeXun SHl,GuiBi QIAN,YunXiang TANG,Yi CUl
Prevalence and rIsk factors of diabetes in schizoprenia inpatients DaChun CHEN,BaoHua ZHANG,ZhiRen WANG,WuFaIlg ZHANG,YunIong TAN,XiangYang ZHANG
PrevaIence and risk factors of depressive symptoms in perimenopausaI and earIy postmenopausal women at a gynecoIogIcaI cinIcin Shanghai Jing TAO,JinYin QlU,Hong Liang GU,HuiLin YANG,Jing CHEN,ZuCheng wANG
Forum
Current status and future trends in clinicaI research of bipolar disorder YiRu FANGl, ZuoWei WANG
BaIancing patients'rights and public safety:rethinking "deinstitutionaIjzation" and "reinstitutjonalization" Bin XIE
Current approaches to compuIsory treatment are hard to justify (unethicaI?) outside of a triaI CIive E.ADAMS
LegaI frameworks for compuIsory treatment(and beyond) Graham MELLSOP,Kate DIESFELD
Commentary
Opening the doors to Chinese Psychiatry Norman SARTORIUS
New direction for the Shanghai Archives of Psychiatry KaiDa JIANG,MichaeI R.PHILLIPS,LiWei WANG
China's contrIbution to the growing literature on rTMS therapy for depression Joseph R.CALABRESE,Keming GAo
Case report
Modified eIectroconvulsive therapy in the treatment of neuroleptic maIignant syndrome Yong YANGl,YongGu HE,Biao WANG
Biostatistics in psychiatry
Significance Testes aanndd Confidence Intervals Naihua DUAN,Yuanjia wANG