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Bing Tian Prof. in Department of Internal Medicine Sealy Center of Molecular Medicine 301 University Blvd. Medical Research Building 8.134 Galveston, Texas 77555-1060 (409) 772-7571 (409) 772-8709 (fax) email: bitian@utmb.edu, bitianster@gmail.com Research Interests Inflammations, Airway Infectious Diseases, and NF-kappaB Signaling Pathways, NF-kB systems biology Advance a novel small molecule inhibitor of the Bromodomain-Containing Protein 4 (BRD4) for the treatment of inflammation-induced remodeling in a novel small animal model. Animal surgery and Animal Electrocardiography, Pharmacological Methodology and New Drug Development Biochemical Analysis, Radioactive Immunoassay, Radioactive and Non-active Labeling and Detection. Cell Culture and Cellular Regulation, Establishing and biologically characterizing regulated stably expression cell lines; DNA Sequencing and Purification, Polymerase Chain Reaction (PCR, including RT-PCR, and Real-time PCR), Molecular Cloning; cDNA Microarray gene chip analysis Regulation of Gene Transcription, Protein expression and analysis, Light microscopy and Electron microscopy; Western Blot, Developing Transgenic Mouse, Non-radioactive in situ Hybridization Real-Time PCR, Confocal Microscopy, Chromatin Inmmunoprecipitation Assay.